Evaluation of vitamin B12 and vitamin D levels in primary school-age children according to different body mass index percentages
Vitamins in obese children
DOI:
https://doi.org/10.5281/zenodo.8408534Keywords:
Children, obesity, vitamin B12, vitamin DAbstract
Objective: It is known that serum levels of various vitamins are low in obese children. We aimed to evaluate whether serum vitamin B12 and vitamin D levels in primary school children aged 7-12 years differ according to body mass index (BMI) percentiles and whether vitamin supplementation should be considered in cases of low vitamin levels.
Methods: The study retrospectively included 129 children admitted to our hospital. Sixty percent of the children were girls and 40% were boys. Their mean age was 8.74±4.86 years. Considering their weight percentiles, 29% of the children were above 95th percentile and 34% were in the 50th percentile. Weight and height were measured while the participants were wearing light clothes and without shoes. Body weight was measured using a digital scale, and BMI (kg/m2) was calculated by dividing weight in kg by the square of height in meters. Demographic and laboratory data (hemoglobin, ferritin, vitamin B12 and vitamin D) were obtained from the laboratory information management system. The results were compared statistically.
Results: The mean vitamin B12 level of children below the 95th percentile was 383.20±162.79 ng/L, and the mean vitamin B12 level of children above the 95th percentile was 328.75±154.59 ng/L (p=0.020). In addition, the mean vitamin D level of children below the 95th percentile was 22.38±10.26 µg/L, and the mean vitamin D level of children above the 95th percentile was 16.00±8.06 µg/L (p=0.001).
Conclusion: According to our study findings, vitamin B12 and vitamin D levels of children above the 95th percentile were lower. Vitamin B12 and vitamin D levels should be measured in obese patients within the scope of preventive health services. Also, necessary vitamin supplementation should be performed upon confirmation of low levels.
References
Aragón-Vela J, Alcalá-Bejarano Carrillo J, Moreno-Racero A, Plaza-Diaz J. The role of molecular and hormonal factors in obesity and the effects of physical activity in children. Int J Mol Sci. 2022;23:15413.
Calcaterra V, Vandoni M, Marin L, Carnevale Pellino V, Rossi V, Gatti A, et al. Exergames to limit weight gain and to fight sedentarism in children and adolescents with obesity. Children. 2023;10:928.
Martinez-Martinez E, Cachofeiro V, Rousseau E, Alvarez V, Calvier L, Fernandez- Celis A, et al. Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation. Mol Cell Endocrinol. 2015;411:20-7.
Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014;21:319-29.
Castano L, Madariaga L, Grau G, García-Castaño A. 25(OH)Vitamin D deficiency and calcifediol treatment in pediatrics. Nutrients. 2022;14:1854.
Savastano S, Barrea L, Savanelli MC, Nappi F, Di Somma C, Orio F, et al. Low vitamin D status and obesity: Role of nutritionist. Rev Endocr Metab Disord. 2017;18:215-25.
Monsen AL, Refsum H, Markestad T, Ueland PM. Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years. Clin Chem. 2003;49:2067-75.
Allen LH. How common is vitamin B-12 deficiency? Am J Clin Nutr. 2009;89:693-6.
Pinhas O, Doran N, Reichman B. Obese children and adolescents: A risk group for vitamin B12 concentration. Arch Pediatr Adolesc Med. 2006;160:933-6.
Narin F, Atabek ME, Karakukcu M, Narin N, Kurtoglu S, Gumus H, et al. The association of plasma homocysteine levels with serum leptin and apolipoprotein B levels in childhood obesity Ann Saudi Med. 2005;25:209-14.
Neyzi O, Bundak R, Gökçay G, Günöz H, Furman A, Darendeliler F, et al. reference values for weight, height, head circumference, and body mass index in Turkish children. J Clin Res Pediatr Endocrinol. 2015;7:280-93.
Halczuk K, Kaźmierczak-Barańska J, Karwowski BT, Karmańska A, Cieślak M. Vitamin B12 Multifaceted In Vivo Functions and In Vitro Applications. Nutrients. 2023;15:2734.
Green R. Vitamin B12 deficiency from the perspective of a practicing hematologist. Blood. 2017;129:2603-11.
Green R, Allen LH, Bjørke-Monsen AL, Brito A, Guéant JL, Miller JW, et al. Vitamin B12 deficiency. Nat Rev Dis Prim. 2017;3:1-20.
Stabler SP. Clinical practice. Vitamin B12 deficiency. N Engl J Med. 2013;368:149-60.
Demir N, Koc A, Üstyol L, Peker E, Abuhandan M. Clinical and neurological findings of severe vitamin B12 deficiency in infancy and importance of early diagnosis and treatment. J Paediatr Child Health. 2013;49:820-4.
Gunanti IR, Marks GC, Al-Mamun A, Long KZ. Low serum vitamin B-12 and folate concentrations and low thiamin and riboflavin intakes are inversely associated with greater adiposity in Mexican American children. J Nutrition. 2014;144:2027-33.
Pinhas-Hamiel O, Doron-Panush N, Reichman B, Nitzan-Kaluski D, Shalitin S, Geva- Lerner L. Obese children and adolescents a risk group for low vitamin B12 concentration. Arch Pediatr Adolesc Med. 2006;160:933-6.
MacFarlane AJ, Greene-Finestone LS, Shi Y. Vitamin B-12 and homocysteine status in a folate-replete population: results from the Canadian Health Measures Survey. Am J Clin Nutr. 2011;94:1079–87.
Fu Y, Zhu Z, Huang Z, He R, Zhang Y, Li Y, et al. Association between Vitamin B and Obesity in Middle-Aged and Older Chinese Adults. Nutrients. 2023;15:483.
Buyukinan M, Ozen S, Kokkun S, Saz EU. The relation of vitamin D deficiency with puberty and insulin resistance in obese children and adolescents. J Pediatr Endocrinol Metab. 2012;25:83-7.
Al-Musharaf S, Al-Othman A, Al-Daghri NM, Krishnaswamy S, Yusuf DS, Alkharfy KM, et al. Vitamin D deficiency and calcium intake in reference to increased body mass index in children and adolescents. Eur J Pediatr. 2012;171:1081-6.
Radhakishun N, van Vliet M, von Rosenstiel I, Weijer O, Diamant M, Beijnen J, et al. High prevalence of vitamin D insufficiency/deficiency in Dutch multi ethnic obese children. Eur J Pediatr. 2015;174:183-90.
Saggese G, Vierucci F, Boot AM, Czech-Kowalska J, Weber G, Camargo CA Jr, et al. Vitamin D in childhood and adolescence: an expert position statement. Eur J Pediatr. 2015;174:565-76.
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