Does the balance of nitric oxide and L-arginine play a role in the development of allergic rhinitis?
The balance of nitric oxide and L-arginine in allergic rhinitis
Keywords:Arginine, human serum amino acids, mass spectrometry, nitric oxide, seasonal allergic rhinitis
Objective: The aim of the present study was to determine the mechanisms that play a role in the etiopathogenesis of seasonal allergic rhinitis (SAR). We investigated whether amino acids are effective in SAR development. The present study was conducted to investigate the presence of an alteration by comparing the serum free amino acid levels between SAR patients and healthy controls.
Methods: Forty-four patients with SAR were enrolled in the study group (Group 1), and thirty-three healthy volunteers were enrolled in the control group (Group 2). Group 1 consisted of the patients who had elevated specific IgE antibodies against at least one of the following, tree, grass, mold spores or mite, according to the allergen- specific IgE antibody test (the inhalant allergen test). They had at least one SAR symptom and had been diagnosed with SAR for at least two years. Levels of twenty-five serum free amino acids in both groups were measured by LC-MS/MS system. Serum nitric oxide (NO) levels were measured by griess reaction in both groups. Nitrate and nitrite levels were used as markers for NO measurement.
Results: The serum free L-arginine level was found to be significantly lower in group 1 (60,96±22,99 ng/ml) as compared to group 2 (86,27±31,35 ng/ml), (p: 0,047). A significant increase was observed in the levels of NO at group 1 (220.64±22.44 pmol/ml) compared with group 2 (165.84±19.32 pmol/ml), (p <0.05).
Conclusion: We think that arginine/NO balance should be taken into consideration in the investigation of the physiopathology of SAR and potential novel therapeutic options.
Greiner AN, Hellings PW, Rotiroti G, Scadding GK. Allergic rhinitis. Lancet. 2011 Dec 17;378(9809):2112-22.
Cingi C, Gevaert P, Mösges R, Rondon C, Hox V, Rudenko M, et al. Multi-morbidities of allergic rhinitis in adults: European academy of allergy and clinical immunology task force report. Clin Transl Allergy 2017;7(1):17.
Manifesto, Advocacy. Tackling the Allergy Crisis in Europe-Concerted Policy Action Needed. 2015.
Valovirta E, Associations ADP. EFA book on respiratory allergies: raise awareness, relieve the burden. 2011.
Khan DA, editor Allergic rhinitis and asthma: Epidemiology and common pathophysiology. Allergy Asthma Proc 2014.
Emeryk A, Emeryk-Maksymiuk J, Janeczek K. New guidelines for the treatment of seasonal allergic rhinitis. Postepy Dermatol Alergol 2019;36(3):255.
Varney VA, Jacobson MR, Sudderick RM, Robinson DS, Irani AM, Schwartz LB, et al. Immunohistology of the nasal mucosa following allergen-induced rhinitis. Am Rev Respir Dis 1992;146:170-6.
Ferreira HH, Lodo ML, Martins AR, Kandratavicius L, Salaroli AF, Conran N et al. Expression of nitric oxide synthases and in vitro migration of eosinophils from allergic rhinitis subjects. Eur J Pharmacol 2002;442(1-2):155-62.
Gleich GJ, Adolphson CR. The eosinophilic leukocyte: structure and function. Adv Immunol 1986;39:177-253.
Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne EA, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet. 1994;343(8890):133-5.
Zanardo RC, Costa E, Ferreira HH, Antunes E, Martins AR, Murad F, et al. Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils. Proc Natl Acad Sci U S A. 1997;94(25):14111-4.
Conran N, Ferreira HH, Lorand-Metze I, Thomazzi SM, Antunes E, de Nucci G. Nitric oxide regulates human eosinophil adhesion mechanisms in vitro by changing integrin expression and activity on the eosinophil cell surface. Br J Pharmacol. 2001;134(3):632-8.
Silkoff PE, Roth Y, McClean P, Cole P, Chapnik J, Zamel N. Nasal nitric oxide does not control basal nasal patency or acute congestion following allergen challenge in allergic rhinitis. Ann Otol Rhinol Laryngol. 1999;108(4):368-72.
Böger RH, Bode-Böger SM, Frölich JC. The l-arginine—nitric oxide pathway: role in atherosclerosis and therapeutic implications. Atherosclerosis 1996;127(1):1-11.
Bi X, Henry CJ. Plasma-free amino acid profiles are predictors of cancer and diabetes development. Nutr Diabetes 2017;7(3):e249-e249.
Butorov EV. Relationship between plasma l-lysine concentrations and levels of HIV-1 RNA. Virulence 2013;4(7):646-53.
Karthik L, Kumar G, Keswani T, Bhattacharyya A, Chandar SS, Bhaskara Rao KV. Protease inhibitors from marine actinobacteria as a potential source for antimalarial compound. PLoS One. 2014;9(3):e90972.
Hong SY, Yang DH, Chang SK. The relationship between plasma homocysteine and amino acid concentrations in patients with end-stage renal disease. J Ren Nutr 1998;8(1):34-9.
Tochikubo O, Nakamura H, Jinzu H, Nagao K, Yoshida H, Kageyama N, et al. Weight loss is associated with plasma free amino acid alterations in subjects with metabolic syndrome. Nutr Diabetes. 2016;6(2):e197.
Celik M, Şen A, Koyuncu İ, Gönel A. Plasma-Free Amino Acid Profiling of Nasal Polyposis Patients. Comb Chem High Throughput Screen. 2019;22(9):657-662.
Kim YS, Maruvada P, Milner JA. Metabolomics in biomarker discovery: future uses for cancer prevention. Future Oncol 2008.
Miyagi Y, Higashiyama M, Gochi A, Akaike M, Ishikawa T, Miura T, et al. Plasma free amino acid profiling of five types of cancer patients and its application for early detection. PloS one 2011;6(9):e24143.
Watanabe A, Higashi T, Sakata T, Nagashima H. Serum amino acid levels in patients with hepatocellular carcinoma. Cancer. 1984;54(9):1875-82.
Hasim A, Aili A, Maimaiti A, Mamtimin B, Abudula A, Upur H. Plasma-free amino acid profiling of cervical cancer and cervical intraepithelial neoplasia patients and its application for early detection. Mol Biol Rep. 2013;40(10):5853-9.
Cascino A, Muscaritoli M, Cangiano C, Conversano L, Laviano A, Ariemma S, et al. Plasma amino acid imbalance in patients with lung and breast cancer. Anticancer Res. 1995;15(2):507-10.
Atila A, Alay H, Yaman ME, Akman TC, Cadirci E, Bayrak B, et al. The serum amino acid profile in COVID-19. Amino Acids. 2021;53(10):1569-88.
Santos CB, Marçal RG, Voltarelli A, de Morais Silva RP, Sakman R. Métodos não farmacológicos de alívio da dor utilizados durante o trabalho de parto normal. Global Academic Nursing Journal. 2020; 1(1), e2-e2.
do Nascimento DT, Koeppe GBO, Oliveira PP, Valadao RR, Prado TDSB, dos Santos NS, et al. Estratégias de saúde para manutenção da qualidade da assistência na quimioterapia no contexto da pandemia da COVID-19. Global Academic Nursing Journal, 2021;2(Spe. 2), e117-e117.
Narzullaev Н. The Characteristic Of The Immune Status At HIV-Infected Children With Acute Rhinosinusitis. International Journal of Scientific Pediatrics, 2022;(3), 40–5.
Seger C, Salzmann L. After another decade: LC-MS/MS became routine in clinical diagnostics. Clin Biochem 2020.
Moshage H, Kok B, Huizenga JR, Jansen PL. Nitrite and nitrate determinations in plasma: a critical evaluation. Clin Chem. 1995;41(6 Pt 1):892-6.
Keles MS, Bayir Y, Suleyman H, Halici Z. Investigation of effects of Lacidipine, Ramipril and Valsartan on DNA damage and oxidative stress occurred in acute and chronic periods following isoproterenol-induced myocardial infarct in rats. Mol Cell Biochem. 2009;328(1-2):109-17.
Felig P. Amino acid metabolism in man. Annu Rev Biochem 1975;44(1):933-55.
Brosnan JT. Interorgan amino acid transport and its regulation. J Nutr 2003;133(6):2068S-2072S.
Christensen HN. Interorgan amino acid nutrition. Physiol Rev 1982;62(4):1193-233.
Kertys M, Grendar M, Kosutova P, Mokra D, Mokry J. Plasma based targeted metabolomic analysis reveals alterations of phosphatidylcholines and oxidative stress markers in guinea pig model of allergic asthma. Biochim Biophys Acta Mol Basis Dis. 2020;1866(1):165572.
Maarsingh H, Zaagsma J, Meurs H. Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives. Br J Pharmacol 2009;158(3):652-64.
Bischoff SC. Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data. Nat Rev Immunol 2007;7(2):93-104.
Azeredo R, Machado M, Fontinha F, Fernández-Boo S, Conceição LEC, Dias J, et al. Dietary arginine and citrulline supplementation modulates the immune condition and inflammatory response of European seabass. Fish Shellfish Immunol. 2020;106:451-63.
Frieri M, editor Nitric oxide in allergic rhinitis and asthma. Allergy and Asthma Proc 1998:349.
Lundberg JO, Weitzberg E, Nordvall SL, Kuylenstierna R, Lundberg JM, Alving K. Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome. Eur Respir J. 1994;7(8):1501-4.
Gerlach H, Rossaint R, Pappert D, Knorr M, Falke KJ. Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx. Lancet. 1994;343(8896):518-9.
Lundberg JO, Farkas-Szallasi T, Weitzberg E, Rinder J, Lidholm J, Anggåard A, et al. High nitric oxide production in human paranasal sinuses. Nat Med. 1995;1(4):370-3.
Martin U. Exhaled nitric oxide levels are increased in association with symptoms of seasonal and perennial allergic rhinitis. Am J Resp Crit Care Med 1995;151:128.
Kharitonov SA, Rajakulasingam K, O'Connor B, Durham SR, Barnes PJ. Nasal nitric oxide is increased in patients with asthma and allergic rhinitis and may be modulated by nasal glucocorticoids. J Allergy Clin Immunol. 1997;99(1 Pt 1):58-64.
Uçmak F, Ekin N, İbiloğlu İ, Arslan S, Kaplan İ, Şenateş E. Prophylactic administration of silybin ameliorates L-arginine-induced acute pancreatitis. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. 2016; 22, 3641.
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