A comparison of propofol and etomidate for anesthesia induction in patients with diabetic autonomic neuropathy

The use of propofol and etomidate

Authors

DOI:

https://doi.org/10.5281/zenodo.7699091

Keywords:

Anesthesia induction, diabetic neuropathy, etomidate, propofol

Abstract

Objective: Diabetic autonomic neuropathy (DAN) is closely related with higher perioperative hemodynamic abnormalities. We predicted that etomidate produces less hemodynamicabnormalities than propofol during anesthesia induction in DAN patients.
Methods: The study included 40 DAN patients that undergo elective abdominal surgery with American Society of Anesthesiology classifications 2 or 3. In Group E, etomidate 0.3 mg/kg was given for induction of anesthesia. In Group P, propofol 2.5 mg/kg was applied for induction of anesthesia. Each group was consisted of 20 patients. Diastolic (DAP), systolic (SAP), mean arterial pressure (MAP) and heart rate (HR) values were measured before anesthesia induction (T0). Following the anesthesia induction, same measurements were conducted every minute for 5 minutes (T1-T5). Before anesthesia induction, following five minutes of endotracheal intubation and the surgical incision, the levels of serum insulin, cortisol and adrenocorticotropic hormone (ACTH) were analyzed.
Results: Average HR measurements were not different among the groups., average HR considerably reduced at T1 compared with T0 in Group P. Average SAP at T2 was noticeably fewer in Group P. Average SAP considerably decreased at T2 in both groups (p0.001) when compared with T0 values. At T1, T2, T3, and T5 times, patients in Group P showed noticeably decreased average DAP values than those in Group E. T1 average DAP noticeably decreased only in Group P (p<0.001) when compared with T0 values. At T1, average MAP was noticeably decreased in Group P compared with Group E (p=0.033). MAP noticeably decreased at T1 in both groups compared with T0 measurements (p≤0.006). Serum levels of ACTH, cortisol, and insulin were not noticeably distinguishable among groups at any measurement time point.
Conclusion: When compared to propofol, etomidate is associated with fewer hemodynamic disturbances during anesthesia induction in diabetic patients with DAN.

References

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Published

2023-03-05

How to Cite

Sarı Küçük, R., & Uzman, S. (2023). A comparison of propofol and etomidate for anesthesia induction in patients with diabetic autonomic neuropathy: The use of propofol and etomidate . The Injector, 2(1), 16–22. https://doi.org/10.5281/zenodo.7699091

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Original Article