Risk factors, incidence and long-term outcomes of premature infants with retinopathy in a single tertiary clinic: Premature infants with retinopathy

Özge Begüm Comba; Muharrem Karakaya

doi:10.5281/zenodo.7028523

Authors

Özge Begüm Comba Yenibosna Safa Hospital, Department of Ophthalmology, İstanbul, Turkey https://orcid.org/0000-0003-1956-3498
Muharrem Karakaya İstanbul Yeni Yüzyıl University, Gaziosmanpaşa Hospital, Department of Ophtalmology, İstanbul, Turkey https://orcid.org/0000-0002-7729-7653

DOI:

https://doi.org/10.5281/zenodo.7028523

Keywords:

Bevacizumab, refractive result, retinopathy of prematurity

Abstract

Objective: The aim of this study is to evaluate the risk factors of patients with retinopathy of prematurity (ROP) in a single tertiary clinic and to present the long-term refractive results of the patients who were treated.

Methods: Premature infants referred to Yeni Yüzyil University hospital or followed in the Neonatal Intensive Care Unit (NICU) of Yeni Yüzyil University hospital between 2017 and 2020 were evaluated retrospectively. In this study, patients were evaluated in three groups according to their gestational weeks (<28 gw, 29-32 gw, >32 gw). According to the Early Treatment Retinopathy Cooperative Group (ETROP) study, treatment was recommended for the infants with Type 1 ROP. Spherical equivalent (SEQ), cylindrical and spherical values of the treated cases were recorded at all follow-ups.

Results: A total of 646 premature babies born before 38 weeks were recorded between 2017 and 2020. 102 infants (15.7%) in group 1, 320 infants (49.53%) in group 2, and 224 infants (34.6%) in group 3 were examined. Among all infants, 18 eyes (1.39%) of 9 infants were treated with only one intravitreal injection of bevacizumab (0.025 ml/0.625 mg). The mean SE and spherical values decreased over time at the 3^rd, 6th and 12^thmonth follow-ups.

Conclusion: ROP can be controlled with an appropriate and effective treatment. Intravitreal injection of bevacizumab is a highly effective treatment option for type 1 ROP disease and Aggressive Posterior ROP. Long-term studies involving more patients are needed to evaluate the effect of treatment options on refractive outcome.

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