Comparison of radiation-induced DNA damage between conventional and computed tomography coronary angiography

Genotoxicity and angiographic radiation




Angiography, chromosome aberration test, ionizing radiation, genotoxicity


Objective: Conventional coronary angiography (CCA) and coronary computed tomography angiography (CCTA) are the most frequently used imaging modalities to diagnose coronary artery disease (CAD). The amount of radiation and genotoxic damage of these imaging methods showed variation with the improved technology. Thus we sought to compare the ionizing radiation doses and radiation-induced DNA damage in patients who were performed CCA and CCTA.
Methods: A total of 76 patients (39 in CCA group, 37 in CCTA group) were enrolled. Patients undergoing CCTA were grouped according to the use of the flash technique (22 patients with CCTA-flash, 15 patients with CCTA-other). The effective radiation dose was recorded. Genotoxicity was compared with the chromosome aberration tests before and after imaging methods.
Results: There was a significant difference between the groups in effective radiation doses given to patients. Radiation was lowest in the CCTA-flash group, followed by CCA, and non-flash CCTA group. There was no change in chromosome aberration rate after CCTA-flash group (p= 0.479). There was a significant increase in chromosome aberration rates after CCA and CCTA-other groups (CCA: p= 0.001; CCTA-other: p= 0.01).
Conclusion: CCTA taken with flash technique in dual-energy CT devices delivers lower dose radiation than other groups. Due to this significant difference, radiation-induced genetic damage was significantly less in patients with CCTA undergoing flash technique.


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How to Cite

Gökalp, G., Ünlü, S., Elkama, A., Yalçın, A. C., Özbeyaz, N. B. ., Cemri, M., Karahalil, B., Erbaş, G., & Boyacı, N. B. (2023). Comparison of radiation-induced DNA damage between conventional and computed tomography coronary angiography: Genotoxicity and angiographic radiation. The Injector, 2(1), 1–8.