Evaluation of the relationship between glycemic parameters and preoperative tumor markers in colorectal, prostate, and breast cancers

Glycemic parameters and preoperative tumor markers





Breast cancer, colorectal cancer, glucose, prostate cancer, tumor markers


Objective: The basic metabolic processes of cancer cells involve growth and proliferation. These cells use glucose as the main source. We aimed to investigate the significance of glycemic parameters and preoperative tumor markers in terms of risk and stage of cancer development.

Methods: We employed a total of 400 participants, including 100 patients diagnosed with colorectal cancer, 100 patients diagnosed with prostate cancer, 100 patients diagnosed with breast cancer, and 100 healthy controls. We evaluated glucose, HbA1c, insulin, carbohydrate antigen 15-3 (CA15-3), carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 72-4 (CA72-4), carcinoembryonic antigen (CEA) and prostate specific antigen (PSA) results of these individuals.

Results: We found significantly higher levels of fasting plasma glucose (FPG) and fasting plasma insulin (FPI) in breast cancer patients; FPG, FPI, and HbA1c in prostate cancer patients; and FPG and HbA1c values in colorectal cancer patients compared to control groups (p<0.05). Furthermore, we found significantly higher CEA and CA15-3 in breast cancer patients; PSA, CEA, and CA19-9 in prostate cancer patients; and CEA, CA19-9, and CA72-4 in colorectal cancer patients compared to those in the control groups (p<0.05).

Conclusion: We confirmed the ability of glucose, insulin, and HbA1c to predict breast, prostate and colorectal cancer. In this context, the successful implementation of glycemic control and diabetes mellitus treatment in patients may enhance the efficacy of the treatment incertain cancers and reduce the incidence of the disease. However, more cohort studies are needed to demonstrate this relationship more clearly and to consider it a rule.


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How to Cite

Öztürk, A., İnandıklıoğlu, N., Balas, Şener, & Karakoyunlu, A. N. (2023). Evaluation of the relationship between glycemic parameters and preoperative tumor markers in colorectal, prostate, and breast cancers: Glycemic parameters and preoperative tumor markers. The Injector, 2(3), 183–196. https://doi.org/10.5281/zenodo.8395853



Original Article