Current treatment of hepatitis C infection

Treatment of hepatitis C




Antiviral agents, direct-acting antivirals, hepatitis C, treatment


Hepatitis C Virus (HCV) is a RNA virus causing HCV infection. HCV infection is an important cause of cirrhosis, hepatocellular carcinoma (HCC), and death. Interferons were the first agents used to treat HCV infection. Low success rates and serious side effects limited the use of interferons. The discovery of direct-acting antivirals (DAAs), stemming from a deep understanding of the virus's structure, life cycle, and viral proteins, has led to significant advancements in treatment. Currently, all patients infected with HCV can be treated with a high success rate. Thanks to pangenotypic treatments, it is not necessary to determine the genotype of the virus before treatment. DAAs are safer in terms of side effects. Cirrhosis status, comorbidities, and drug-drug interactions should be considered when planning treatment. The World Health Organization (WHO) aims to eliminate hepatitis C infection by 2030. In order to achieve this elimination, patients need to be diagnosed and receive effective treatment. DAAs are effective tools to achieve this aim. In this review, the microbiology, epidemiology, diagnosis, and treatment of HCV infection are presented. Treatment is described in detail from past to present.


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How to Cite

Emre, S. (2024). Current treatment of hepatitis C infection: Treatment of hepatitis C . The Injector, 3(1), 24–29.