Experience of Measles-Mumps-Rubella vaccine among children with egg allergy: Measles-Mumps-Rubella vaccine and egg allergy

Uğur Altaş; Ayşen  Çetemen; Zeynep Meva   Altaş; Emre   Akkelle; Mehmet Yaşar   Özkars; Mahmut   Doğru

doi:10.5281/zenodo.10498457

Authors

Uğur Altaş University of Health Sciences, Umraniye Training and Research Hospital, Department of Pediatric Allergy and Immunology , Istanbul, Turkey https://orcid.org/0000-0001-5871-2033
Ayşen Çetemen University of Health Sciences, Umraniye Training and Research Hospital, Department of Pediatric Allergy and Immunology , Istanbul, Turkey https://orcid.org/0000-0001-6129-3554
Zeynep Meva Altaş Ümraniye District Health Directorate, Istanbul, Turkey https://orcid.org/0000-0003-0475-8946
Emre Akkelle University of Health Sciences, Sancaktepe Training and Research Hospital, Department of Pediatric Allergy and Immunology, İstanbul, Turkey https://orcid.org/0000-0003-2112-3432
Mehmet Yaşar Özkars University of Health Sciences, Umraniye Training and Research Hospital, Department of Pediatric Allergy and Immunology , Istanbul, Turkey https://orcid.org/0000-0003-1290-8318
Mahmut Doğru İstanbul Arel University Faculty of Medicine, Department of Pediatrics, İstanbul, Turkey https://orcid.org/0000-0001-9728-8028

DOI:

https://doi.org/10.5281/zenodo.10498457

Keywords:

Anaphylaxis, children, egg allergy, measles-mumps-rubella vaccine

Abstract

Objective: Due to the egg protein contained in the vaccine, patients with egg allergy have had hesitations about Measles-Mumps-Rubella (MMR) vaccination for a long time. We aimed to share our clinical experience on this subject.

Methods: In the descriptive type of study, all 179 patients with egg allergy and received MMR in our clinic between 2015-2022 were included. Age, gender, clinical findings, allergy tests, total IgE, eosinophil values, post-vaccine reaction status were evaluated retrospectively.

Results: The median age of those vaccinated in our clinic is 13.0 months (9.0-84.0). The median value for the calendar delay in the vaccine dose is 1.0 months (min: 0, max: 72.0). The median absolute eosinophil value of the patients was 360.0 10³/uL (10.0-2220.0), the median eosinophil value (%) was 3.4% (0.1-20.0%), and the median total IgE value was 53.5 IU/mL (1.0-2500.0). The most common clinical findings were atopic dermatitis and urticaria (54.7% and 44.1%, respectively). There was no patient who developed anaphylaxis before. A post-vaccine reaction developed in 1 of 179 children who received MMR vaccine. Urticaria was observed in this patient. No serious reaction was observed in any of the patients.

Conclusion: Children with egg allergy should be evaluated by pediatric allergy clinics; however, this should not cause a delay in the MMR vaccination schedule.

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