Two unclear issues in Hashimoto's disease; gluten-free diet and selenium support: Gluten-free diet and selenium in Hashimoto's disease

Ferit Kerim Küçükler

doi:10.5281/zenodo.11153985

Authors

Ferit Kerim Küçükler Private İçerenköy Bayındır Hospital, Department of Endocrinology, İstanbul, Turkey https://orcid.org/0000-0002-9277-0584

DOI:

https://doi.org/10.5281/zenodo.11153985

Keywords:

Celiac disease, Hashimoto's disease, gluten, selenium

Abstract

Hashimoto's disease is one of the most common endocrine disorders in society. Although the accepted standard treatment is hormone replacement, social media has offered nutritional supports based on a gluten-free diet and selenium supplementation. I aimed to clarify this issue by reviewing the literature for awareness of clinicians.

References

Abbott RD, Adam S, Angela GA. Efficacy of the autoimmune protocol diet as part of a multi-disciplinary, supported lifestyle intervention for Hashimoto’s thyroiditis. Cureus. 2019;11:4.

Kaličanin D , Brčić L , Barić A , Zlodre S , Barbalić M , Lovrić VT, et al. Evaluation of Correlations Between Food-Specific Antibodies and Clinical Aspects of Hashimoto’s Thyroiditis. J Am Coll of Nutr. 2019;38:259-66.

Lucyna O, Gier D, Zyśk B. The Influence of Reducing Diets on Changes in Thyroid Parameters in Women Suffering from Obesity and Hashimoto’s Disease. Nutrients. 2021;13.3:862.

Robert K, Szkróbka W, Okopień B. The effect of gluten-free diet on thyroid autoimmunity in drug-naive women with Hashimoto’s thyroiditis: A pilot study. Exp Clin Endocrinol Diabetes. 2019;127:417-22.

Kus K, Zielińska K, Zaprutko T, Ratajczak P, Nowakowska E. Choroba Hashimoto–efektywność diety bezglutenowej. Pol Prz Nauk Zdr. 2016:4;370-6.

Vaivode I, Zake T, Strele I, Upmale-Engela S, Gogins D, Gersone G, et al. Stress-Related Immune Response and Selenium Status in Autoimmune Thyroid Disease Patients. Int J Mol Sci. 2023;24:2440.

Tian X, Li N, Su R, Dai C, Zhang R. Selenium supplementation may decrease thyroid peroxidase antibody titer via reducing oxidative stress in euthyroid patients with autoimmune thyroiditis. Int J Endocrinol. 2020; 9210572.

Wang W, Mao J, Zhao J, Lu J, Yan L, Du J, et al. Decreased thyroid peroxidase antibody titer in response to selenium supplementation in autoimmune thyroiditis and the influence of a selenoprotein P gene polymorphism: a prospective, multicenter study in China. Thyroid. 2018;28:1674-81.

Hao R, Yu P, Gui L, Wang N, Pan D, Wang S. Relationship between serum levels of selenium and thyroid cancer: A systematic review and meta-analysis. Nutr Cancer. 2022;75:14-23.

Negro R, Greco G, Mangieri T, Pezzarossa A, Dazzi D, Hassan H. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Clin Endocrinol Metab. 2007;92:1263-8.

Lanzolla G, Marinò M, Marcocci C. Selenium in the treatment of Graves’ hyperthyroidism and eye disease. Front Endocrinol. 2021;11:608428.