Do insulin resistance and inflammation parameters change according to the blood types in non-obese healthy individuals? Insulin resistance  and inflammation

Orkun Sarıçam

doi:10.5281/zenodo.8072274

Authors

Orkun Sarıçam Ankara Pursaklar State Hospital, Department of Internal Medicine, Ankara, Turkey https://orcid.org/0000-0001-5820-0951

DOI:

https://doi.org/10.5281/zenodo.8072274

Keywords:

ABO blood type, insulin resistance, inflammation, obesity

Abstract

Objective: Insulin resistance (IR) is defined as a decrease in insulin sensitivity in tissues targeting insulin and is a risk factor for many diseases. In this study, we aimed to elucidate the relationship of insulin resistance, inflammation parameters and blood groups in non-obese healthy individuals.

Methods: A total of 275 volunteers without any chronic disease who applied for check-up were included in the study. Demographic characteristics, body mass index, biochemical parameters, hemogram and blood types of the patients were recorded and compared between groups.

Results: Of the 17.5% (n=48) individuals who had insulin resistance and those with BMI <25 were included in the study. C-reactive protein (CRP), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and systemic immune-inflammatory index (SII) values were significantly higher in those with IR than those without IR (p<0.05). In those with IR, the rate of those with AB blood group was found to be significantly higher than the rate of those with blood group 0 (p=0.017).

Conclusion: We found that subclinical chronic inflammation indicators such as NLR, PLR, SII and CRP were significantly higher in non-obese and healthy individuals with IR than those without IR. Curative treatments to be initiated in the early period in individuals with IR may provide additional therapeutic benefits beyond lowering glucose, preventing metabolic diseases.

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